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. 2022 Mar 19;11(6):1047. doi: 10.3390/cells11061047

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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NA recordings in the cerebellar granular layer. (A) Example of a vermis and hemisphere cerebellar slice placed on the HD-MEA biochip (scale bar 0.5 mm). The activity following single-pulse stimulation of mossy fibers is superimposed in a color-scale (2 ms bin). A representative trace is shown from the HD-MEA biochip channel indicated by the arrow. The stimulus intensity and stimulating electrode is the same as used in Figure 1B. The inset shows the entire N₁-N_2a-N_2b-P₂ complex that comprises the classic LFP in the granular layer (see Methods for details). (B) The histograms show the average peak amplitude of N_2a and N_2b, for both the vermis and hemisphere (n = 10 slices for both) and the single data points. Statistical significance is indicated by asterisks (*** p < 0.001).