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. 2022 Feb 11;11:e70278. doi: 10.7554/eLife.70278

Figure 9. Stim1-smKO mice are hypotensive.

(A) Systolic blood pressure (BP) (mmHg) over 48 hr in conscious, radio telemeter-implanted Myh11CreERT2: Stim1fl/fl mice before (control) and after (Stim1-smKO) tamoxifen injection. Shaded regions depict night cycles (n = 5 for both groups; *p<0.05 vs. control day, #p<0.05 vs. control night, paired t-test). (B) Diastolic BP measurements for control and Stim1-smKO mice (n = 5 for both groups, paired t-test). ns, not significant. (C) Mean arterial pressure (MAP) for control and Stim1-smKO mice (n = 5 for both groups, #p<0.05 vs. control night, paired t-test). ns, not significant. (D) Pulse pressure for control and Stim1-smKO mice (n = 5 for both groups; *p<0.05 vs. control day, #p<0.05 vs. control night, paired t-test). (E) Heart rate (HR) for control and Stim1-smKO mice (n = 5 for both groups, paired t-test). ns, not significant. (F) Locomotor activity (arbitrary units [AU]) for control and Stim1-smKO mice (n = 5 for both groups, paired t-test). ns, not significant. 48 hr recordings are shown as means; bar graphs are shown as means ± SEM.

Figure 9—source data 1. Individual data points and analysis summaries for datasets shown in Figure 9.
elife-70278-fig9-data1.xlsx (518.6KB, xlsx)

Figure 9.

Figure 9—figure supplement 1. Blood pressure, heart rate and activity remain unaltered in Myh11CreERT2: Stim1fl/fl mice after vehicle injection.

Figure 9—figure supplement 1.

(A) Systolic blood pressure (BP) (mmHg) over 48 hr in conscious, radio telemeter-implanted Myh11CreERT2: Stim1fl/fl mice before (control) and after vehicle injection. Shaded regions depict night cycles (n = 5 for both groups, paired t-test). (B) Diastolic BP measurements for Myh11CreERT2: Stim1fl/fl mice before and after vehicle injection (n = 5 for both groups, paired t-test). (C) Mean arterial pressure (MAP) for Myh11CreERT2: Stim1fl/fl mice before and after vehicle injection (n = 5 for both groups, paired t-test). (D) Pulse pressure for Myh11CreERT2: Stim1fl/fl mice before and after vehicle injection (n = 5 for both groups, paired t-test). (E) Heart rate (HR) for Myh11CreERT2: Stim1fl/fl mice before and after vehicle injection (n = 5 for both groups, paired t-test). (F) Locomotor activity (arbitrary units [AU]) for Myh11CreERT2: Stim1fl/fl mice before and after vehicle injection (n = 5 for both groups, paired t-test). ns, not significant. 48 hr recordings are shown as means; bar graphs are shown as means ± SEM.
Figure 9—figure supplement 1—source data 1. Individual data points and analysis summaries for datasets shown in Figure 9—figure supplement 1.