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Tepro dose-dependently inhibits TED-Ig-induced HA secretion. Dose-response inhibition by Tepro was measured in TEDOFs (see Materials and Methods) stimulated with 4.9 mg/mL TED-Igs pooled from 37 patients. Secreted hyaluronan (HA) was measured in the conditioned media as described in Materials and Methods. Data represent the mean ± SD of biological duplicates in each strain.
