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. 2022 Apr 1;13(2):423–432. doi: 10.14336/AD.2021.0913

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Copyright: © 2022 Schwartz et al.

this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 1. — The inhibition of G6PD and NADPH production by DHEA and related steroids. DHEA is a potent uncompetitive inhibitor (with respect to NADP+ and glucose-6-phosphate) of mammalian G6PD and thereby reduces the availability of NADPH and generation of reactive oxygen species by NADPH-dependent enzymes. Reprinted from Schwartz, AG, Pashko, LL, “Dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and longevity,” Aging Research Reviews, 2004, 3, 171-187, by permission of Elsevier.