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. 2022 Apr 1;13(2):583–613. doi: 10.14336/AD.2021.0829

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Copyright: © 2022 Attaluri et al.

this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 10. — Twelve weeks of nCUR treatment in rats with chronic GWI reduced NLRP3 inflammasome formation in the hippocampus. Figures A-X illustrate examples of NLRP3 inflammasomes in IBA-1+ microglia (A-L) and NeuN+ neurons (M-X) from the CA3 subfield of naïve control (A-D, M-P), GWI-VEH (E-H, Q-T), GWI-nCUR (I-L, U-X) groups. The bar charts in Y-AE compare concentrations of NF-kB (Y), NLRP3 (Z), caspase-1 (AA), and IL-18 (AB), the number of inflammasomes/unit area (AC), the percentage of microglia with inflammasomes (AD), and the percentage of neurons with inflammasomes (AE). All of these measures except caspase 1 and the percentage of inflammasomes in neurons were upregulated in the GWI-VEH group but significantly reduced in the GWI-nCUR group. Scale bar, A-L = 25 μm; M-X = 12.5 μm; *, p<0.05, **, p<0.01, ***, p<0.001; NS, not significant.