Figure 1.

Schematic model for role of FoxO1 in apoptosis. After stroke, activation of PI3K/Akt pathway is suppressed. Then the phosphorylation of FoxO1 and the interaction between p-FoxO1 and 14-3-3 are inhibited which further lead to the nuclear translocation and activation of FoxO1. After FoxO1 is activated, downstream apoptosis pathway including TRAIL, Fas Ligand and Bim are also regulated accordingly. The solid lines represent the pathway that occurs after stroke, and the dotted lines represent the pathway suppressed after stroke.