Table1.
Treatments and Intervention Measures Targeting FoxO1 Post-stroke.
| 1. Detrimental Targets of FoxO1 | |
|---|---|
| Parecoxib | Significantly inhibits the nuclear translocation of FoxO1 and its target gene-CHOP in a dose-independent manner |
| Lithium | Restores decreased activation of Akt 24 h after ischemia, which is associated with increased phosphorylation of FoxO1 |
| 7,8-Dihydroxyflavone (7,8-DHF) | Attenuates brain tissue damage, causing Akt activation in neurons, with enhancing FoxO1 phosphorylation and decreasing the cellular apoptosis after ICH |
| Galangin | Inhibits the expression of MMP-9 stimulated by thrombin via blocking the FoxO1 cascade in SK-N-SH cells |
| KY-226 | Protects the integrity of BBB by restoring the TJ protein mediated by FoxO1 inhibition, thereby protecting neurons from cerebral ischemic injury |
| Melatonin | Prevents the injury-induced reduction of p-Akt, p-FoxO1, and increases the interaction of p-FoxO1 with 14-3-3, which leads to reduced cell apoptosis |
| Bone marrow stem cells (BMSCs) | Decreases cell apoptosis and upregulates the expression of survivin, increasing phosphorylation of FoxO1 |
| 17β-estradiol | Prevents injury-induced decrease of p-Akt and p-FoxO1 during ischemia stroke |
| Sal (8-O-b-d-glucoside of tyrosol) | Protects against cerebral I/R injury through the inhibition of FoxO1 activation |
| Pre-conditioning | Prevents injury-induced decrease p-FoxO1 during ischemia stroke |
| 2. Protective Targets of FoxO1 | |
| OX26-PEG-Se NPs | Activates FoxO1/Catalase/SOD to inhibit oxidative injury |
| Calycosin-7-O-β-D-glucoside (CG) | Alleviates oxygen glucose deprivation/reoxygenation-induced damage via the inhibition production of ROS through activating of SIRT1/FoxO1 signaling pathway |
| Alvianolic acid B (SalB) | Upregulates the expression of SIRT1 and Bcl-2 and downregulates the expression of acetylated-FoxO1 and Bax |
| Piceatannol (Pic) | Plays antioxidant and neuroprotection effects via activation of SIRT1/FoxO1 pathway |
| Magnolol | Increases the expression of SIRT1, leading to the downregulation of Ac-FoxO1 and activation of the synthesis of antioxidants to protect against oxidative stress injury |