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. 2022 Mar 25;39(2):110680. doi: 10.1016/j.celrep.2022.110680

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Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Comparison of immune transcriptomes between COVID-19 recovered and SARS-CoV-2 naive cohorts after BNT162b2 vaccination

(A) Heatmaps showing log2 FC (top, red) and corresponding p adj. (bottom, ocher) of significantly upregulated genes between day 0 and day 1 in COVID-19 recovered (left) and SARS-CoV-2 naive (right) cohorts. The genes specifically activated between day 0 and day 1 and still induced by day 7 are listed in Tables S11 and S12.

(B) Venn diagram displays the number of significantly induced genes between day 0 and day 1 in both cohorts. GSEA analysis is in Figure S5.

(C) Heatmaps showing log2 FC (top) and corresponding p adj. (bottom) of genes significantly activated at day 7 in COVID-19 recovered (left) and SARS-CoV-2-naive (right) cohorts. The genes induced between day 0 and day 7 fall into different categories based on their activation pattern (Tables S11 and S12).