Figure 5.

Boosting with ancestral or Omicron-matched vaccine provides equivalent protection in the lungs against Omicron challenge

(A–E) BAL (A and D), NS (B and E), and OS (C) were collected at the indicated times following challenge with 1 × 10⁶ PFU Omicron.

(A–C) Omicron sgRNA_N copy numbers per mL of BAL (A) or per swab (B and C).

(D and E) Viral titers per mL of BAL (D) or per swab (E).

Circles indicate individual NHP. Boxes represent interquartile range with the median denoted by a horizontal line. Assay LOD indicated by dotted lines. Statistical analysis shown for cohorts boosted with mRNA-1273 (red text) or mRNA-Omicron (blue text) in comparison with controls at each timepoint. 8 controls and 4 vaccinated NHP per boost cohort. See also Figure S10 for Omicron challenge stock sequence.