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. 2022 Mar 25;185(9):1556–1571.e18. doi: 10.1016/j.cell.2022.03.038

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Virus antigen and pathology in the lungs after challenge

(A and B) 2 NHP per group were euthanized on day 8 postchallenge and tissue sections taken from lungs.

(A) Left: representative images indicating detection of SARS-CoV-2 N antigen by immunohistochemistry with a polyclonal anti-N antibody. Antigen-positive foci are marked by a red arrow. Right: hematoxylin and eosin stain (H&E) illustrating the extent of inflammation and cellular infiltrates. Images at 10× magnification with black bars for scale (100 μm).

(B) SARS-CoV-2 antigen and inflammation scores in the left cranial lobe (Lc), right middle lobe (Rmid), and right caudal lobe (Rc) of the lungs. Antigen scoring legend: − no antigen detected; +/− rare to occasional foci; + occasional to multiple foci; ++ multiple to numerous foci; +++ numerous foci. Inflammation scoring legend: − absent to minimal inflammation; +/− minimal to mild inflammation; + mild to moderate inflammation; ++ moderate-to-severe inflammation; +++ severe inflammation. Horizontal rows correspond to individual NHP depicted above (A).