Figure S1.

Experimental timeline and responses to Omicron sublineages after boost, related to Figure 1

(A) 8 NHP were vaccinated with 100 μg of mRNA-1273 at weeks 0 and 4. At week 41, NHP were split into 2 groups of 4 and boosted with 50 μg of mRNA-1273 or mRNA-Omicron. Both groups, and 8 unvaccinated NHP which were given 50 μg of mRNA control, were challenged with Omicron 1 month later.

(B) Sera were collected 2 weeks postboost to measure pseudoneutralizing responses to D614G and the BA.1 and BA.2 sublineages of Omicron. Circles indicate individual NHP. Boxes represent interquartile range with the median denoted by a horizontal line. Assay LOD indicated by dotted line. 4–6 NHP per group.