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. 2022 Mar 25;185(9):1556–1571.e18. doi: 10.1016/j.cell.2022.03.038

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Figure S8 — Both mRNA-1273 and mRNA-Omicron boost T cell responses to S peptides, related to Figure 4

(A–E) PBMC collected at weeks 0, 6, 41, and 44 post-immunization. Cells were stimulated with SARS-CoV-2 S1 and S2 peptide pools (WA1) and then measured by intracellular cytokine staining.

(A and B) Percentage of memory CD4+ T cells with (A) T_H1 markers (IL-2, TNF, or IFNγ) or (B) T_H2 markers (IL-4 or IL-13) following stimulation.

(C) Percentage of CD8+ T cells expressing IL-2, TNF, or IFNγ.

(D and E) Percentage of T_FH cells that express (D) CD40L or (E) IL-21.

(F–H) BAL fluid was collected at weeks 8, 39, and 43 post-immunization. Lymphocytes in the BAL were stimulated with S1 and S2 peptide pools (WA1) and responses measured by intracellular cytokine staining using T_H1 (F), T_H2 (G), and CD8 markers (H). Break in y axis indicates a change in scale without a break in the range depicted.

Circles in (A–H) indicate individual NHP. Boxes represent interquartile range with the median denoted by a horizontal line. Dotted lines set at 0%. Reported percentages may be negative due to background subtraction and may extend below the range of the y axis. 8 vaccinated NHP, split into 2 cohorts postboost. 4 control NHP shown for comparison.