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. 2022 Mar 25;76:102178. doi: 10.1016/j.coi.2022.102178

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© 2022 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Genome organization, virion structure, and overview of protein-level mutations in SARS-CoV-2 strains. (a) Genomic organization of SARS-CoV-2. ORF1a and ORF1b encode 16 nonstructural proteins (NSP1–NSP16). NSP3 and NSP5 (ORF1a) encode the papain-like protease and 3CL-protease, respectively. NSP12 encodes RNA-dependent RNA polymerase (RdRp) and NSP13 encodes RNA helicase (ORF1b). The structural genes encode the structural proteins: (S) Spike, (E) Envelope, (M) Membrane, and (N) Nucleocapsid. (b) SARS-CoV-2 virion structure. (c) Overview of protein-level mutations of SARS-CoV-2 strains [35]. Figure created with Biorender.com.