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. 2022 Jun 14;55(6):1105–1117.e4. doi: 10.1016/j.immuni.2022.03.019

Figure 1.

Figure 1

Antibodies to different domains of SARS-CoV-2 S have distinct patterns of V gene usage

(A) The frequency of different V gene pairings between heavy and light chains are shown for SARS-CoV-2 S antibodies to RBD, NTD, and S2. The size of each data point represents the frequency of the corresponding IGHV/IGK(L)V pair within its epitope category. Only those antibodies where both IGHV and IGK(L)V information is available for both heavy and light chains were included in this analysis.

(B) The IGHV gene usage in antibodies to NTD, RBD, and S2 is shown. Only those antibodies with IGHV information available were included in this analysis.

(C) The IGK(L)V gene usage in antibodies to NTD, RBD, and S2 is shown. Only those antibodies with IGK(L)V information available were included in this analysis.

(B and C) Error bars represent the frequency range among 26 healthy donors (Briney et al., 2019; Guo et al., 2019; Soto et al., 2019). See also Figure S1 and Tables S1 and S2.