Table 7.
Comparison of calculated and weighted final scores between patients with eosinophilic esophagitis and nondysphagia controls for S-EEsAI and EORTC QLQ-OES18
| Patients mean (SD) | Nondysphagia control mean (SD) | Fold change | p valuea | |
|---|---|---|---|---|
| S-EEsAI | ||||
| VDQ | 12 (7.3) | 0.87 (3.1) | 14 | < 0.001 |
| AMS | 2.1 (5.6) | 0.26 (2.5) | 8.1 | < 0.001 |
| Frequency | 14 (11) | 1.1 (3.9) | 13 | < 0.001 |
| Duration | 0.37 (1.5) | 0.0 (0.0) | – | 0.013 |
| Pain | 3.2 (6.2) | 0.15 (1.5) | 22 | < 0.001 |
| PRO | 32 (22) | 2.4 (7.3) | 13 | < 0.001 |
| EORTC QLQ-OES18 | ||||
| Dysphagia | 6.7 (11) | 6.6 (23) | 1.0 | 0.001 |
| Swallowing saliva | 14 (27) | 2.4 (13) | 5.8 | < 0.001 |
| Choking | 20 (28) | 4.8 (12) | 4.2 | < 0.001 |
| Eating | 18 (21) | 1.8 (5.1) | 10 | < 0.001 |
| Dry mouth | 16 (26) | 6.5 (14) | 2.5 | 0.0049 |
| Taste | 1.7 (7.3) | 1.0 (7.6) | 1.7 | 0.26 |
| Cough | 13 (22) | 6.8 (16) | 1.9 | 0.020 |
| Speech | 4.4 (13) | 1.0 (5.7) | 4.4 | 0.026 |
| Reflux | 18 (22) | 7.2 (15) | 2.5 | < 0.001 |
| Pain | 12 (14) | 3.2 (6.4) | 3.8 | < 0.001 |
AMS avoidance, modification and slow eating score; Duration duration of trouble swallowing; EORTC QLQ-OES18 European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Oesophageal Module 18; Frequency frequency of trouble swallowing; Pain pain when swallowing; PRO patient-reported outcome score; SD standard deviation; S-EEsAI Swedish Eosinophilic Esophagitis Activity Index; VDQ visual dysphagia question
S-EEsAI calculated scores: VDQ: 0–23; AMS: 0–25; Frequency: 0–31; Duration: 0–6; Pain: 0–15; PRO: 0–100 [15]. Each of the EORTC QLQ-OES18 domains are scored from 0 to 100 [10]
aMann–Whitney U test