Table 2.
Summary of top loci identified by meta-analysis of TZFG and 500FG dataset
| Loci | SNPs | Chr | Base pair | Cytokines | Stimulation | Z score | Meta p value | TZFG p value | 500FG p value | Allelic direction | Causal genes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | rs60372900 | 5 | 178,220,798 | TNF-a | S. aureus | 5.47 | 4.50 × 10−8 | 6.56 × 10−3 | 1.24 × 10−6 | ++ | AACSP1a |
| 2 | rs1919482 | 8 | 19,754,718 | IL-6 | C. albicans | 5.353 | 8.69 × 10−8 | 2.31 × 10−5 | 5.78 × 10−4 | ++ | LPL,a,bINT,bCSGALNCb |
| 3 | rs1602850 | 12 | 86,657,959 | IL-1b | S. aureus | 5.281 | 1.29 × 10−7 | 1.13 × 10−4 | 2.54 × 10−4 | ++ | MGAT4Ca |
| 4 | rs1588730 | 4 | 89,955,623 | IFN-g | C. albicans | 5.26 | 1.44 × 10−7 | 2.70 × 10−5 | 8.05 × 10−4 | ++ | FAM13A,a,bTIGD2b |
| 5 | rs6002586 | 22 | 42,441,412 | IL-1b | C. albicans | 5.18 | 2.22 × 10−7 | 9.63 × 10−4 | 6.57 × 10−5 | ++ | WBP2NL,aSMDT1,bCYP2D6,bMEI1,bNAGA,bPHETA2b |
| 6 | rs6801434 | 3 | 100,809,977 | IL-6 | S. aureus | 5.108 | 3.25 × 10−7 | 2.22 × 10−4 | 3.51 × 10−4 | ++ | ABI3BP,aTFGb |
| 7 | rs16829318 | 3 | 158,418,720 | TNF-a | C. albicans | 5.032 | 4.87 × 10−7 | 4.08 × 10−4 | 3.12 × 10−4 | ++ | RARRES1,aLXN,bGFM1,bMLF1,bRSRC1b |
| 8 | rs2949663 | 1 | 167,391,498 | TNF-a | LPS | −4.935 | 8.00 × 10−7 | 6.17 × 10−4 | 3.55 × 10−4 | – | POU2F1,aCD247,bAL359962.1b |
| 9 | rs3755369 | 2 | 70,942,964 | IFN-g | LPS | 4.84 | 1.30 × 10−6 | 1.30 × 10−3 | 2.93 × 10−4 | ++ | ADD2,a,bCLEC4Fb |
| 10 | rs6864825 | 5 | 173,659,256 | IFN-g | S. aureus | −4.794 | 1.64 × 10−6 | 1.40 × 10−4 | 2.16 × 10−3 | – | HMP19a |
| 11 | rs11122458 | 1 | 230,308,855 | IL-6 | LPS | 4.768 | 1.86 × 10−6 | 2.51 × 10−3 | 2.25 × 10−4 | ++ | GALNT2a |
| 12 | rs2485164 | 9 | 1,706,565 | IL-1b | LPS | 4.761 | 1.93 × 10−6 | 1.00 × 10−3 | 5.48 × 10−4 | ++ | SMARCA2a |
a
The gene in closest proximity to the cytokine QTL SNPs.
b
Expression of this gene shows association with cytokine QTL SNP in whole blood.