Table 1.

Studies included in the meta-analysis.

Study	Study design	Demographics comparability	Country	Patients syndrom included	No patients	Endpoints included	Mean follow-up (Y)
De Feyter10	Prespecified analysis—arts trial	Unadjusted	Netherlands	Unstable angina	450	MORTl, MACE, MI, RR	1
Chew11	Post-hoc analysis—synergy trial	Unadjusted	Australia	Unstable angina and NSTEMI	9902	MORTl, MI	0.5
Hochholzer12	Prospective cohort study	Multivariable regression	Germany	Unstable angina and NSTEMI	1024	MORTl, MI	1.3
Alhabib13	Prospective study—gulf race-2 registry	Unadjusted	Saudi Arabia	Unstable angina and NSTEMI	802	MORTp, MORTl	1
Roe14	Retrospective—crusade registry	Unadjusted	United States	NSTEMI	15,281	MORTl, MACE, RR	3.2
Buszman15	Prospective study—milestone registry	Propensity score matching	Poland	Unstable angina and NSTEMI	4566	MORTp, MORTl	3
Ben-Gal16	Post-hoc analysis—acuity trial	Propensity score matching	Israel	Unstable angina and NSTEMI	1772	MORTp, MORTl, MACE, MI, RR	1
Kurlansky17	Retrospective—care registry	Propensity score matching	United States	NSTEMI	3228	MACE	5.6 (CABG) AND 5.1 (PCI)
Chang18	Patient level data—best/precombat/syntax	Unadjusted	South Korea	Unstable angina and NSTEMI	1246	MORTl, MACE, MI, RR	5
Freitas19	Prospective observational study	Multivariable regression	Portugal	NSTEMI	688	MORTl	4.8
Huckaby20	Retrospective	Multivariable regression	United States	NSTEMI	2001	MORTl, MACE, MI, RR	3.6
Jia21	Prospective observational study	Multivariable regression	China	Unstable angina and NSTEMI	2819	MORTl, MACE, MI, RR	7.5
Ram22	Prospective study –acsis registry	Multivariable regression	Israel	Unstable angina and NSTEMI	5112	MORTp, MORTl	3

CABG coronary artery bypass grafting, MACE major adverse cardiovascular events, MI myocardial infarction, MORTl long-term mortality, MORTp peri-operative mortality, NSTEMI non-ST-elevation myocardial infarction, PCI percutaneous coronary intervention, RR re-revascularization.