Table 2.

Outcomes summary.

Outcome	Studies no.	Patients no.	Random effect estimate (95% CI), p-value	Fixed effect estimate (95% CI), p-value	Heterogeneity (I2, p-value)
Long-term mortality	12	26,725	IRR 0.93 [0.70; 1.23], p = 0.61	IRR 0.80 [0.75; 0.85], p < 0.001	88.1%, p < 0.001
Long-term MACE	8	24,519	IRR 0.64 [0.54; 0.76], p < 0.001	IRR 0.69 [0.65; 0.73], p < 0.001	77.4%, p < 0.001
Long-term re-revascularization	6	22,573	IRR 0.37 [0.30; 0.47], p < 0.001	IRR 0.37 [0.30; 0.47], p < 0.001	42.7%, p = 0.11
Long-term myocardial infarction	7	7572	IRR 0.96 [0.50; 1.84], p = 0.61	IRR 1.56 [1.41; 1.74], p < 0.001	93.0%, p < 0.001
Peri-operative mortality	5	4334	OR 1.36 [0.94; 1.95], p = 0.10	OR 1.36 [0.94; 1.95], p = 0.10	60.0%, p = 0.83
Long-term stroke	6	13,197	IRR 0.96 [0.72; 1.28], p = 0.81	IRR 0.96 [0.72; 1.28], p = 0.81	0.0%, p = 0.497
Late MACE plus stroke	5	6842	IRR 0.67 [0.50; 0.90], p = 0.007	IRR 0.72 [0.66; 0.79], p < 0.001	86.9%, p < 0.001

CI confidence interval, IRR incidence rate ratio, MACE major adverse cardiovascular events, No number, OR odds ratios.