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. 2022 Mar 24;12:5140. doi: 10.1038/s41598-022-09195-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) The rate of controlled drug release in various formulations of Niosome-encapsulated Imipenem compared to free Imipenem. (B) the impact of temperature on average size and encapsulation efficiency (C) of F1 and F2 formulation of Niosome-encapsulated Imipenem (ns, p > 0.05, ** p < 0.01, * p < 0.05. n = 3).