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. 2022 Mar 24;8:130. doi: 10.1038/s41420-022-00935-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A Correlation between UBE2C expression and CTRP drug sensitivity. B MTT was used to detect the cytotoxicity of sorafenib to THCA cells for 24 h. C Cytotoxic effect of sorafenib on the THCA cells with UBE2C knockdown. D The UBE2C protein expression in THCA cells with UBE2C knockdown was detected by western blot. The THCA cells were treated with different doses of sorafenib.