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. 2022 Mar 24;8:41. doi: 10.1038/s41523-022-00398-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a The summed histogram of [⁶⁸Ga]RGD uptake of all tumors and all time points was fitted and analyzed as described above for [¹⁸F]FDG, resulting in a sum of 3 Gaussian distributions as the best model. The thresholds 0.7 and 1.6%ID/cc were applied to the histograms of the single time points. b Representative PET/MR images revealed the highest uptake population (red, > 1.6%ID/cc) in only large tumors.