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. 2022 Mar 24;8:41. doi: 10.1038/s41523-022-00398-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Proliferation zones and tumor areas are highly proliferative compared with differentiation zones. Ki67 stained MIN-O tissues at 7-week a–f and 10-week g–l were analyzed for cell proliferation m, n. Images were analyzed at proliferation zone a, d, g, j, differentiation zones b, e, h, k and tumor areas (indicated as AdenoCa; c, f, i, l. The analysis for Ki67 positive cells were performed on QuPath by identifying nuclear Ki67 signals. Images shown as “PosNeg” indicate red cells as Ki67 positive and blue cells as Ki67 negative. The densities of Ki67 positive cells (positive percentage) were analyzed at proliferation zones, differentiation zones and tumor areas in m 7-week and n 10-week MIN-O tissues. Bars represent mean value ± standard deviation. m Scale bar indicates 100 µm. All images were adjusted to same magnification.