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. 2022 Mar 24;12:5132. doi: 10.1038/s41598-022-09241-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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LAS194046 and fluticasone propionate combination shows additive/synergic effects on human neutrophil inflammation. Neutrophils from healthy subjects, severe asthma and COPD patients were pre-incubated with sub-effective concentrations of LAS194046, fluticasone propionate or its combination during 1 h followed by cell stimulation with (A) LPS (1 µg/ml) or (B) cigarette smoke extract (CSE 5%) for 6 h to measure IL-8 and MMP-9 release. The results are expressed as the mean ± SD (n = 3 each for cells from healthy controls, severe asthma and COPD patients in independent experiments with triplicate samples). A two-way ANOVA was followed by a post hoc Bonferroni test. *p < 0.05 vs. cells from healthy patients.