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. 2022 Mar 24;12:5132. doi: 10.1038/s41598-022-09241-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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LAS194046 and fluticasone propionate combination shows additive/synergic effects inhibiting the phosphorylation of JAK2/STAT3 and ERK1/2-P38 pathways in neutrophils from severe asthma and COPD patients. Neutrophils from severe asthma and COPD patients were pre-incubated with sub-effective concentrations of LAS194046, fluticasone propionate or its combination during 1 h followed by cell stimulation with LPS (1 µg/ml) for 1 h to measure the phosphorylation of (A) JAK2/STAT3 and (B) ERK1/2-P38 by western blot. Extended blots are presented in Supplementary Figs. S1 and S2 online. The results are expressed as the mean ± SD (n = 3 each for cells from severe asthma and COPD patients). A one-way ANOVA was followed by a post hoc Bonferroni test. *p < 0.05 vs. control; ^#p < 0.05 vs fluticasone propionate monotherapy; ^┴p < 0.05 vs monotherapy.