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. 2022 Mar 24;12:5116. doi: 10.1038/s41598-022-08915-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of orally administered B. amyloliquefaciens (BA) or BA-nanoparticles (BANPs) in non-colitic and colitic rats on fecal lipocalin-2 (Lcn-2) levels 7 days post DSS induction. Non-colitic groups including Control, BA and BANPs groups where rats were orally gavaged PBS, B. amyloliquefaciens and B. amyloliquefaciens loaded nanoparticles (BA at level of 1.0 × 10¹⁰ CFU/kg in 1 mL of PBS/rat/day), respectively, for 7 days. Colitic groups: DSS, BA and BANPs groups where rats were orally gavaged dextrane sodium sulphate (DSS), B. amyloliquefaciens + DSS and B. amyloliquefaciens loaded nanoparticles (BA at level of 1.0 × 10¹⁰ CFU/kg in 1 mL of PBS/rat/day) + DSS, respectively, for 7 days. All groups orally gavaged by 5% DSS. Values are expressed as mean ± SE, ^a,b,cMeans of the bars with different letters were significantly different among groups (P < 0.05).