Table 2. The Inflammatory and Cellular Function of the JAK/STAT Pathway.

Pathways	Cellular Function	Major Disease	Cytokines and Factor
STAT1	Cell growth and apoptosis TH1 cell-specific cytokine production Antimicrobial defense	Atherosclerosis Infection Immune disorders	IL-2, IL-6, IL-10, IFN-a, IFN-b, IFN-g, IL-27
STAT2	Mediation of IFN/IFN signal	Cancer Infection Immune disorders	IFN-a, IFN-b
STAT3	Cell proliferation and survival Inflammation Immune response Embryonic development Cell motility	Cancer	LIF, IL-10, IL-6, IL-27, Growth hormone
STAT4	TH1 cell differentiation Inflammatory responses Cell proliferation	Experimental autoimmune encephalomyelitis (EAE) (multiple sclerosis; MS) Systemic lupus erythematosus	IL-12
STAT5a	Cell proliferation and survival IL-2R expression in T lymphocytes Mammary gland development Lactogenic signaling	Cancer, chronic myelogenous Leukemia	Prolactin, growth hormone, thrombopoietin
STAT5b	Cell proliferation and survival IL-2R expression in T lymphocytes Sexual dimorphism of body growth rate NK cell cytolytic activity	Cancer, chronic myelogenous leukemia
STAT6	Inflammatory and allergic immune response B cell and T cell proliferation	Asthma, allergy	IL-4, IL-13
JAK1	Cellular proliferation, immune cell division, phosphorylation, and activation of transcription factors (STAT)		IL-2, IL-7, IL-9, IL-15, IL-4, IL-13, IL-6, IL-11,
JAK2			IL-3, IL-12, IL-13, IL-6, IL-11, IFN-gama, CT-1,
JAK3			IL-2, IL-7, IL-9, IL-15, IL-4
TyK2	Dendritic cell differentiation, pro-inflammatory TH cell response, TH2 responses	Hyper IgE syndrome, Job's syndrome	IL-6, IL-11, IL-12, IL-13, CT-1, IFN-α, IFN-β,