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. 2022 Mar 24;8:40. doi: 10.1038/s41523-022-00402-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a A volcano plot shows that 15 proteins (red dots) changed significantly (FDR <0.05, S0 of 1) upon SFN treatment. b A volcano plot shows that 128 localized phosphorylation sites (red dots) changed significantly (FDR <0.05, S0 of 1) upon SFN treatment. c Cluster analysis of differentially expressed proteins. d Cluster analysis of differentially expressed phosphorylation sites. e The core network of protein–protein interaction map of the altered proteins and phosphoproteins that are illustrated with color by clusters and size by degree. MAPK1, TP53, and PTK2 are in the top three degrees and served with a red border. The nodes involved in the regulation of the actin cytoskeleton are displayed by arrows. f KEGG pathways enrichment of core altered proteins and phosphoproteins.