Table 3.

Stop pathway recommendations and research priorities.

Gap	Action	Outcome
An understanding of mechanisms driving the MS prodrome	Fund research into early detection of MS before accumulation of neurological deficit	Processes contributing to MS risk are clearly defined; therapeutic interventions are implemented at the earliest point in time, leading to improved clinical outcomes
Longitudinal biomarker studies	Enhance the impact of cohorts, registries, and repositories Facilitate access and utilization by MS research community Promote best practices in biomarker development and evaluation	Existing and new biomarkers enable early detection of disease activity
Research based framework to select the best therapy for individual patients (e.g., precision medicine)	Promote research to provide clinical validation of multi-modal biomarker approaches to predict response to therapy. Foster collaboration between diverse biomarker fields	Robust multi-modal biomarkers are fully integrated into clinical practice guidelines to support clinical decisions Partnerships are expanded to develop and implement better tools for precision medicine
Therapies for progressive forms/stages of MS	Promote investment in clinical testing of therapeutics that modulate pathways in progressive MS	Putting a stop to both relapsing and progressive injury mechanisms in each individual patient

MS: multiple sclerosis.