Table 4.

Restore pathway recommendations and research priorities.

Gap	Action	Outcome
Physiologic mechanisms involved in regeneration and repair	Design and conduct studies to understand the role of aging, sex, genetics and other factors associated with regeneration	Identification of new targets for promoting myelin repair
MS specific outcome measures (biologic, imaging and clinical) that are sensitive to regeneration and/or functional recovery	Develop consensus around the identification of outcome measures Design and conduct research to identify outcomes that: Can detect and measure myelin regeneration Can detect meaningful recovery of function Are associated with both regeneration and meaningful recovery of function	Identification of outcomes that can be used in clinical trials to test pharmacologic and rehabilitation interventions, and once approved can be used to guide use of therapies in clinical practice
Trial design, that fosters the development of rehabilitation and wellness interventions	Advance guidance of clinical trial design Facilitate and fund clinical intervention trials that target functional recovery, symptom management, rehabilitation, or wellness strategies	Clinical intervention trials are implemented and evidence from those trials are used for the development of clinical guidelines
Standard outcomes across clinical trials	Promote the use of standardized of outcomes across rehabilitation and wellness clinical trials Develop consensus around standard outcomes to remotely measure and monitor functional recovery	Existing and new outcomes measures are identified and used for clinical trials

MS: multiple sclerosis.