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RET rearrangement in human cancer. A. Breakpoints in the RET gene. The breakpoints of RET often occur within intron 11 and less frequently within introns 7 and 10 (indicated by arrows). B. Representative RET rearrangement identified in human cancers. PTC, papillary thyroid carcinoma; TM, transmembrane domain; TK, tyrosine kinase domain.
