Figure 3.

(Color online) A molecular and neural circuit models for integrating temperature and oxygen signaling in cold acclimation. (A): Ca²⁺ imaging for ADL thermosensitivity in the mutants impairs potassium channels, KQT-2 and KQT-3. The relative increase or decrease in Ca²⁺ concentration in ADL of each strain is measured as a changing the YFP/CFP fluorescence ratio of the cameleon protein (Ratio change). These channels act in ADL thermal responsiveness. Data source: Okahata et al. (2019).²⁴⁾ (B): A neuronal circuit model for integrating temperature signaling of ADL with oxygen signaling from URX visceral oxygen sensory neurons via RMG hub interneurons. (C): ADL activity is positively regulated by TRP channels OCR-2 or OSM-9, and is negatively regulated by the potassium channel KQT-3. OSM-9/OCR-2 and KQT-3 are genetically inhibited by OCR-1 and KQT-2, respectively.