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. 2022 Mar 7;13:781404. doi: 10.3389/fendo.2022.781404

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Copyright © 2022 Dai, Yi, Wang, Xia, Tao, Wu, Miao and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PQQ treatment improved the fertility and ovarian function of female mice treated with CTX in combination with BUL (CTX/BUL). (A) Record of estrous cycles of mice for each day, n = 6 mice in each group. (B) Estrous cycle period distribution for 30 consecutive days, n = 6 mice in each group. (C) Fertility test of female mice, n = 7 mice in each group. (pregnancy mice/total mice). (D) Days from mating to delivery, n = 7 mice in each group. ELISA analysis of serum (E) AMH, (F) FSH and (G) E2 levels, n = 4 samples in group Con, n=7 samples in group O, and n=5 samples in group OP. D, diestrus; M, metestrus; E, estrus; P, proestrus; AMH, anti-Mullerian hormone; FSH, follicle-stimulating hormone; E2, estradiol; PQQ, pyrroloquinoline; CTX, cyclophosphamide; BUL, busulfan. Compared with Con: *P < 0.05; **P < 0.01; ***P < 0.001; compared with O: ^#P < 0.05; ^###P < 0.001.