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. 2022 Mar 7;13:781404. doi: 10.3389/fendo.2022.781404

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Copyright © 2022 Dai, Yi, Wang, Xia, Tao, Wu, Miao and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PQQ treatment promoted ovarian cell proliferation and inhibited ovarian cell apoptosis and senescence in the female mice treated with CTX/BUL. (A) Representative photos of ovarian sections stained with anti-BrdU antibody, n = 3 mice in each group. (B) Representative photos of TUNEL assay on ovarian sections, n = 3 mice in each group. (C) Representative photos of ovarian sections stained with anti- β-gal antibody, n = 3 mice in each group. q-PCR analysis of ovarian extracts to detect the expression of the (D) Bmi1 gene, n = 6 mice in each group, (E) p21 gene, n = 6 mice in each group, (F) p27 gene, n = 6 mice in each group, (G) p53 gene, n = 6 mice in each group, (H) Bax gene, n = 6 mice in each group, (I) Noxa gene, n = 6 mice in each group and (J) puma gene, n = 6 mice in each group. PQQ, pyrroloquinoline; CTX, cyclophosphamide; BUL, busulfan. Compared with Con: *P < 0.05; **P < 0.01; ***P < 0.001; compared with O: ^#P < 0.05; ^##P < 0.01.