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. 2022 Mar 7;10:836680. doi: 10.3389/fbioe.2022.836680

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Copyright © 2022 Weinberg.

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(A) Difference between uptake of albumin downstream and upstream of intercostal branch ostia, expressed as a percentage of the mean uptake in both regions. Uptake is greater downstream in young rabbits and greater upstream in older rabbits (Sebkhi and Weinberg, 1994a). (B) Maps showing the prevalence of spontaneous lipid deposition around intercostal branch ostia in weanling (left) and aged (right) rabbits fed a normal diet. The centre of the ostium is marked with an “X,” mean aortic flow is from top to bottom and increased lesion prevalence is indicated by numbers (% of branches affected at each site) and by darker shading (Barnes and Weinberg, 1998). (C) Similar maps of lesion prevalence in immature and mature rabbits fed a cholesterol-enhanced diet (Cremers et al., 2011). (D) Average extent of lesions from the lip of intercostal ostia (shaded circle) in human fetuses, neonates and infants up to the age of 1 year. Arrow shows mean flow direction (after Sinzinger et al., 1980).