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. 2022 Mar 7;10:836680. doi: 10.3389/fbioe.2022.836680

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Copyright © 2022 Weinberg.

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(A) The effect of the NO inhibitor L-NMMA on the pattern of albumin uptake upstream and downstream of intercostal branch ostia in the in situ-perfused rabbit aorta. Positive values indicate greater uptake downstream and negative values indicate greater uptake upstream, as in Figure 3A. L-NMMA reversed the normal mature pattern of uptake but had no effect on the pattern in immature rabbits (Forster and Weinberg, 1997). (B) A similar but smaller effect was seen in mature rabbits in vivo (Staughton and Weinberg, 2004b). (C) The same trend was seen in mature rabbits when the intercostal arteries were occluded in anaesthetised mature rabbits, whereas sham operation had no effect (Staughton et al., 2001).