Table 5.
Associations of LMP-1 viremia with endemic Burkitt lymphoma in the EMBLEM Study.
| Characteristic | eBL cases (%) | Controls (%) | Crude OR (95% CI) | Adjusted OR (95% CI)* |
|---|---|---|---|---|
| EBV PCR | ||||
| Negative | 18 (4.4%) | 86 (20.8%) | Ref. | Ref. |
| Positive | 396 (95.6%) | 328 (79.2%) | 5.76 (3.40-9.79) | 3.83 (2.06-7.14) |
| EBV Sequence | ||||
| Not successful | 132 (33.3%) | 231 (70.4%) | Ref. | Ref. |
| Successful | 264 (67.7%) | 97 (29.6%) | 4.76 (3.47-6.53) | 8.28 (5.27-13.0) |
| EBV Pattern | ||||
| Sequencing not successful | 132 (33.3%) | 231 (70.4%) | Ref. | Ref. |
| A | 73 (18.4%) | 18 (5.5%) | 7.09 (4.06-12.4) | 11.4 (5.89-22.0) |
| A/B | 43 (10.9%) | 19 (5.8%) | 3.96 (2.21-7.07) | 5.58 (2.62-11.9) |
| D | 82 (20.7%) | 28 (8.5%) | 5.12 (3.17-8.27) | 7.68 (4.09-14.4) |
| K | 52 (13.1%) | 24 (7.3%) | 3.79 (2.23-6.43) | 7.90 (3.98-15.7) |
| Other (E, I, L) | 14 (3.55%) | 8 (2.4%) | 3.06 (1.25-7.47) | 7.98 (2.43-26.3) |
*Adjusted for sex, age group (5 categories), P. falciparum infection, country, village characteristics (rural and proximity to surface water), and anemia (hemoglobin <11.6 g/dl).