Fig. 1.

GGPPS1 knockout ameliorated VILI in mice. C57BL/6 mice with lung-specific GGPPS1 knockout (GGPPS1^−/−) and wild-type (WT) mice were subjected to mechanical ventilation (VT) or not. a Lung injury was analyzed by HE staining and b lung injury was scored. c Mouse lungs were collected for calculation of the wet-to-dry ratio. d Total protein levels in BALF were analyzed using a BCA kit. e Neutrophils in BALF were analyzed by flow cytometry. ns, not significant; *P < 0.05; **P < 0.01; ***P < 0.001 vs. the indicated group