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. 2021 Nov 3;6(4):692–709. doi: 10.1002/hep4.1845

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© 2021 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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FIG. 5 — Ablation of Opn in hepatocytes drives the emergence of CSCs. (A,B) Immunofluorescence of CD44 (red) and AFP (green) (markers of CSCs) in the aggregate fraction of primary hepatocytes from WT, Opn ^Hep Tg, Alb.Cre ⁺, and Opn ^ΔHep 5 months after DEN injection. Red arrow, CD44⁺AFP⁻ cells; green arrow, CD44⁻AFP⁺ cells; and yellow arrow, CD44⁺AFP⁺ cells (CSCs). (C) Number of CSCs by group based on computer‐assisted morphometry analysis of the immunostaining of the aggregate fraction (n = 3/group, mean ± SEM). *P < 0.05. Abbreviation: NS, not significant.