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. 2021 Nov 3;6(4):692–709. doi: 10.1002/hep4.1845

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© 2021 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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FIG. 7 — Secreted OPN has limited effect on CSC proliferation and progression to HCC. (A) Experimental approach to study the effect of rOPN on primary hepatocytes and CSCs (n = 3/group). (B‐D) Experimental approach to study the role of extracellular OPN on CSC progression to cancer, representative gross appearance of the livers, and number of tumors in both groups (mean ± SEM). (E) Representative gross appearance of livers from Cd44 ^−/− (n = 14) and Cd44 ^−/− Opn ^Hep Tg (n = 14) mice injected with DEN and sacrificed 12 months later. (F) Number of macroscopic tumors per mouse liver (mean ± SEM).