TABLE 3.
Univariate and Multivariate Analyses of Patient Clinical and Demographic Characteristics of FIB‐4 With All‐Cause Mortality
| All‐Cause Mortality | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P Value | aHR (95% CI) | P Value | |
| Diagnostic group | ||||
| RISK | 1 (reference) | 1 (reference) | ||
| NAFLD | 1.15 (1.02‐1.28) | 0.018 | 1.15 (1.02‐1.29) | 0.018 |
| NASH | 1.33 (0.88‐2.01) | 0.175 | 1.14 (0.75‐1.72) | 0.540 |
| Sex | ||||
| Female | 1 (reference) | 1 (reference) | ||
| Male | 1.15 (1.05‐1.25) | 0.002 | 0.99 (0.91‐1.08) | 0.820 |
| Race/ethnicity | ||||
| White | 1 (reference) | 1 (reference) | ||
| Black/African American | 0.93 (0.8‐ 1.06) | 0.256 | 0.78 (0.68‐0.89) | <0.001 |
| Hispanic | 0.99 (0.77‐1.27) | 0.919 | 1.01 (0.79‐1.30) | 0.920 |
| Other | 0.91 (0.7‐1.18) | 0.480 | 0.95 (0.73‐1.24) | 0.711 |
| Clinical characteristics | ||||
| T2DM | 1.17 (1.07‐1.28) | <0.001 | 0.97 (0.87‐1.07) | 0.534 |
| Hypertension | 0.92 (0.77‐1.11) | 0.403 | ‐ | ‐ |
| MACE* | 2.93 (2.68‐3.2) | <0.001 | 2.53 (2.31‐2.78) | <0.001 |
| Hyperglycemia | 1.37 (1.26‐1.5) | <0.001 | 1.25 (1.14‐1.37) | <0.001 |
| High LDL‐C | 0.7 (0.63‐0.77) | <0.001 | 0.85 (.077‐0.94) | 0.002 |
| Low HDL‐C | 1.19 (1.09‐1.29) | <0.001 | 1.07 (0.98‐1.17) | 0.148 |
| High triglycerides | 0.85 (0.77‐0.93) | <0.001 | 0.83 (0.75‐0.91) | <0.001 |
| FIB‐4 | ||||
| <1.3 | 1 (reference) | 1 (reference) | ||
| 1.3‐2.66 | 1.24 (1.12‐1.38) | <0.001 | 1.13 (1.02‐1.26) | 0.020 |
| ≥2.67 | 3.19 (2.83‐3.60) | <0.001 | 2.49 (2.20‐2.82) | <0.001 |
Statistical analyses were performed using Cox regression and results were reported as HR and 95% CI.
*
MACE included myocardial infarction, unstable angina, heart failure, and coronary revascularization, including coronary artery bypass graft and stroke.
Abbreviation: aHR, adjusted HR.