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. 2022 Jan 17;9(9):2102620. doi: 10.1002/advs.202102620

Figure 4.

Figure 4

Screening of CRC‐derived sEV‐miRNAs that induce PD‐L1 expression. A) Heatmap of miRNA levels in sEVs derived from CCC‐HIE‐2(CCC), NCM460, SW480, SW620, LoVo, or HCT116 cells. B,C) Candidate miRNAs were validated in sEVs derived from B) CRC cells or plasma samples of C) CR patients using qRT‐PCR. D) The expression levels of PD‐L1 in THP‐1‐derived macrophages transfected with miR‐21‐5p, miR‐92‐3p miR‐1246, and miR‐200a were determined by qRT‐PCR and western blotting. * p < 0.05, ** p < 0.01, *** p < 0.001.