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. 2022 Jan 17;9(9):2105587. doi: 10.1002/advs.202105587

Figure 3.

Figure 3

Hepatic Sdhaf4 knockout improves systemic metabolic sensitivity in mice. a) Fasting glucose and b) fasting insulin in both male and female mice at the age of 4 and 10 weeks, n = 8 for control mice, n = 6 for Sdhaf4 Alb KO mice. c) Glucose tolerance test, d) pyruvate tolerance test, and e) insulin tolerance test in male control and Sdhaf4 Al b KO mice at the age of 4 and 24 weeks separately. f) Immunoblots analysis of p‐Akt level in iWAT, muscle, and liver tissues of control and Sdhaf4 Alb KO mice with or without insulin challenge, n = 6. g,h) Glucose tolerance test and insulin tolerance test in Sdhaf4 Alb KO mice after adenovirus‐mediated hepatic Sdhaf4 overexpression for 2 weeks, n = 6. Values are mean ± SEM, *p < 0.05, **p < 0.01.