TABLE 1.
Association Between P‐NRF2 and Patient Clinicopathological Factors
| Characteristic | P‐NRF2‐Low (n=214) | P‐NRF2‐High (n = 121) | P Value |
|---|---|---|---|
| Age (years) | 70 (64‐77) | 69 (63‐76) | 0.8083 |
| Sex, male/female | 154/60 | 87/34 | 0.9904 |
| BMI (kg/m2) | 22.96 (20.79‐25.35) | 23.67 (21.68‐25.85) | 0.1614 |
| Diabetes mellitus | 71 (33.1%) | 38 (31.4%) | 0.7394 |
| HBs‐Ag‐positive | 37 (17.2%) | 20 (16.5%) | 0.8587 |
| HCV‐Ab‐positive | 108 (50.4%) | 58 (47.9%) | 0.6560 |
| Albumin (g/dL) | 4.0 (3.8‐4.2) | 3.9 (3.7‐4.3) | 0.1081 |
| Child‐Pugh classification, grade B | 6 (2.8%) | 5 (4.1%) | 0.5346 |
| AFP (ng/mL) | 8.9 (4.0‐48.1) | 16.9 (4.8‐417) | 0.0229 |
| DCP (mAU/mL) | 99 (25‐418) | 105 (27‐793) | 0.3388 |
| Tumor size (cm) | 3.2 (2.4‐4.8) | 3.4 (2.3‐5.5) | 0.5961 |
| Solitary/multiple | 178/36 | 98/23 | 0.6139 |
| BCLC staging, B or C | 27 (12.6%) | 22 (18.1%) | 0.1661 |
| Gross classification, single nodular type | 129 (60.3%) | 80 (66.1%) | 0.2896 |
| Poorly differentiated | 40 (18.6%) | 48 (39.6%) | < 0.0001 |
| Microscopic vascular invasion | 62 (28.9%) | 34 (28.1%) | 0.8652 |
| Microscopic intrahepatic metastasis | 22 (10.2%) | 23 (19.0%) | 0.0244 |
| F3 or F4 | 86 (40.1%) | 52 (42.9%) | 0.6184 |
The data are presented as n (%) or median (IQR).
Abbreviations: BCLC, Barcelona Clinic Liver Cancer; BMI, body mass index; DCP, des‐gamma‐carboxyprothrombin; HBs‐Ag, hepatitis B surface antigen; and HCV‐Ab, hepatitis C virus antibody.