TABLE 2.
Univariate and Multivariate Analyses of Factors Related to RFS and OS in Patients With HCC Who Had Undergone Hepatic Resection (Cox Proportional Hazards Analysis)
| Factor | RFS | OS | |||
|---|---|---|---|---|---|
| Univariate Analysis | Multivariate Analysis | Univariate Analysis | Multivariate Analysis | ||
| HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | ||
| P Value | P Value | P Value | P Value | ||
| Age (years) | 1.008 (0.995‐1.022) | 1.025 (1.005‐1.048) | 1.030 (1.005‐1.057) | ||
| 0.2126 | 0.0161 | 0.0180 | |||
| Sex | Male | 1.351 (0.965‐1.892) | 0.858 (0.558‐1.320) | ||
| Female | 0.0796 | 0.4886 | |||
| Diabetes mellitus | Positive | 0.947 (0.698‐1.285) | 0.928 (0.594‐1.449) | ||
| Negative | 0.7273 | 0.7439 | |||
| HBsAg | Positive | 0.909 (0.628‐1.314) | 0.758 (0.442‐1.299) | ||
| Negative | 0.6130 | 0.3146 | |||
| HCV‐Ab | Positive | 1.115 (0.840‐1.479) | 1.593 (1.058‐2.398) | 1.760 (1.087‐2.850) | |
| Negative | 0.4489 | 0.0255 | 0.0214 | ||
| Albumin | 0.526 (0.379‐0.735) | 0.559 (0.398‐0.790) | 0.345 (0.219‐0.549) | 0.456 (0.268‐0.782) | |
| 0.0001 | 0.0009 | < 0.0001 | 0.0040 | ||
| Child‐Pugh classification | B | 1.227 (0.576‐2.614) | 2.122 (0.924‐4.872) | ||
| A | 0.5953 | 0.0757 | |||
| AFP | 1.000 (1.000‐1.000) | 1.000 (1.000‐1.000) | 1.000 (1.000‐1.000) | 0.999 (0.999‐1.000) | |
| < 0.0001 | 0.0079 | 0.0050 | 0.2074 | ||
| DCP | 1.000 (1.000‐1.000) | 0.999 (0.999‐1.000) | 1.000 (1.000‐1.000) | 0.999 (0.999‐1.000) | |
| 0.0063 | 0.6907 | 0.0392 | 0.2037 | ||
| Tumor size | 1.101 (1.048‐1.153) | 1.021 (0.947‐1.093) | 1.124 (1.055‐1.190) | 1.059 (0.945‐1.181) | |
| < 0.0001 | 0.5678 | 0.0001 | 0.3040 | ||
| Macroscopic tumor number | Multiple | 2.209 (1.560‐3.070) | 1.314 (0.775‐2.227) | 2.061 (1.313‐3.234) | 2.190 (0.975‐4.914) |
| Single | < 0.0001 | 0.3106 | 0.0017 | 0.0573 | |
| BCLC staging | B or C | 2.972 (2.091‐4.224) | 1.615 (0.890‐2.932) | 3.698 (2.399‐5.700) | 3.537 (1.591‐7.860) |
| 0 or A | < 0.0001 | 0.1148 | < 0.0001 | 0.0019 | |
| Poorly differentiated | Present | 1.565 (1.149‐2.131) | 0.961 (0.673‐1.372) | 1.859 (1.232‐2.804) | 1.004 (0.604‐1.669) |
| Absent | 0.0044 | 0.8286 | 0.0031 | 0.9854 | |
| Microscopic vascular invasion | Present | 1.447 (1.071‐1.955) | 1.294 (0.920‐1.818) | 2.016 (1.352‐3.004) | 1.498 (0.927‐2.423) |
| Absent | 0.0160 | 0.1378 | 0.0006 | 0.0986 | |
| Microscopic intrahepatic metastasis | Present | 3.379 (2.318‐4.924) | 2.144 (1.299‐3.538) | 3.379 (2.107‐5.416) | 2.592 (1.301‐5.163) |
| Absent | < 0.0001 | 0.0028 | < 0.0001 | 0.0067 | |
| Microscopic liver fibrosis | F3 or F4 | 1.292 (0.972‐1.716) | 1.519 (1.019‐2.263) | 1.891 (1.214‐2.946) | |
| F0, F1, or F2 | 0.0768 | 0.0399 | 0.0048 | ||
| P‐NRF2 | High | 1.787 (1.334‐2.395) | 1.952 (1.430‐2.664) | 2.270 (1.521‐3.388) | 1.910 (1.234‐2.955) |
| Low | < 0.0001 | < 0.0001 | < 0.0001 | 0.0037 | |
Abbreviations: BCLC, Barcelona Clinic Liver Cancer; DCP, des‐gamma carboxyprothrombin; HBsAg, hepatitis B surface antigen; and HCV‐Ab, hepatitis C virus antibody.