Table 2.
Association between p53 immunoreactivity and stem-like features.
| Total No. | p53 Immunoreactivity | ||||||
|---|---|---|---|---|---|---|---|
| 262 | (100%) | Wild-Type 59 (23%) |
Overexpression 143 (55%) |
Cytoplasmic Expression 10 (4%) |
Complete Loss 50 (19%) |
p-Value | |
| CDX2 | 0.0031 | ||||||
| Positive | 233 | [89%] | 44 [75%] † | 132 [92%] | 10 [100%] | 47 [94%] | |
| Decreased or lost | 29 | [11%] | 15 [25%] | 11 [8%] | 0 [0%] | 3 [6%] | |
| ALCAM | 0.0016 | ||||||
| Positive | 76 | [29%] | 26 [44%] | 28 [21%] †† | 3 [30%] | 19 [38%] | |
| Negative | 186 | [71%] | 33 [56%] | 115 [79%] | 7 [70%] | 31 [62%] | |
| Stem-like immunophenotype | 0.19 | ||||||
| Positive | 10 | [4%] | 5 [8%] | 3 [2%] | 0 [0%] | 2 [4%] | |
| Negative | 252 | [96%] | 54 [92%] | 140 [98%] | 10 [100%] | 48 [96%] | |
Fisher’s exact test with post hoc test (Holm) was used to calculate p-values. †: p = 0.043 vs. complete loss, p = 0.012 vs. overexpression. ††: p = 0.0045 vs. wild-type.