Table 1.

Attributable burden of disease for 15 exposure–response relationships in Canada.

Exposure Response Relationship	Target Population	Base Case Estimate	Sensitivity Analyses
Neurodevelopmental deficits
PBDE and IQ points loss and intellectual disability	All neonates	374,395 IQ points lost; 1610 ID cases	790,865–925,481 IQ points lost; 3674–4491 ID cases
OP and IQ points loss and intellectual disability	All neonates	152,922 IQ points lost; 377 ID cases	50,014–201,497 IQ points lost; 111–522 ID cases
Multiple exposures and ADHD	Children aged 12 years	180 cases (OPs)	329 cases (PBDE)
Phthalates and autism	Children aged 8 years	118 cases in males, 28 cases in females	47–236 cases in boys, 11–56 cases in girls
Metabolic disorders
DDE and childhood obesity	Children aged 10 years	114 cases	318 cases
DDE and adult diabetes	Adults aged 40–59 years	3270 cases	36,209 cases
DEHP and adult obesity	Women aged 40–59 years	2093 cases	NA
DEHP and adult diabetes	Women aged 40–59 years	225 cases	NA
BPA and childhood obesity	Children aged 4 years	1023 cases	711 cases
Male reproductive disorders
PBDE and testicular cancer	Men aged 20–79 years	316 cases	96–423 cases
PBDE and cryptorchidism	All male neonates	567 cases	NA
Phthalates and male infertility resulting in increased assisted reproductive technology	Men aged 20–39 years	1395 cases	NA
Phthalates and low testosterone resulting in increased early mortality	Men aged 60–79 years	3385 cases	NA
Female reproductive disorders
DDE and fibroids	Women aged 15–54 years	2254 cases	NA
DEHP and endometriosis	Women aged 20–39 years	10,151 cases	NA

PBDE = polybrominated diphenyl ethers, OP = organophosphate pesticides, DDE = dichlorodiphenyldichloroethylene, DEHP = di-2-ethylhexylphthalate, IQ = intellectual quotient, NA = alternative inputs not available for sensitivity analyses, ADHD = attention deficit hyperactivity disorder.