Table 3.
Evaluation of GRADE pro-GDT.
| Certainty Assessment | № of Patients | Effect | Certainty | ||||||
|---|---|---|---|---|---|---|---|---|---|
| № of Studies | Study Design | Risk of Bias | Inconsistency | Indirectness | Imprecision | Other Considerations | Relative (95% CI) | ||
| 6 | Observational studies | Not serious | Not serious 1 | Not serious | Serious | All plausible residual confounding would suggest spurious effect, while no effect was observed Dose–response gradient |
351 | HR: 1.29 (1.16 to 1.44) | ⨁⨁⨁ 2 Moderate |
1 In three studies, the HR value was extrapolated from the Kaplan–Meier curves reported in the manuscripts; this is not free from errors and can be a source of inaccuracy.2 Certainty: ⨁⨁⨁ moderate.