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. 2022 Mar 18;15(3):371. doi: 10.3390/ph15030371

Figure 20.

Figure 20

Injectable thermosensitive hydrogels for cancer vaccines. Step 1: Sustainable release of GM-CSF from the injectable thermosensitive mPEG- PLGA hydrogels recruits host dendritic cells (DCs) to the site of administration. Step 2: Viral or nonviral vectors carrying immunogens can be delivered in situ to the resident DCs in hydrogels to enhance antigen uptake efficiency, thereby improving anticancer immunity. Reprinted with permission from ref. [63]. Copyright © 2014 Biomacromolecules, American Chemical Society.