Table 2.

Selected genes predicted to be involved in protein metabolism, carbohydrate metabolism and transport, lipid metabolism and transport and response to oxidative stress. It is shown the Fold Change Value. Experimental groups 1 and 2 refer to “engorged vs. unfed—non-infected” and “Borrelia duttonii-infected vs. non-infected—engorged”, respectively.

UniProt_ID	Protein Name	Organism	Gene Ontology (GO)	Experimental Group	log2 Fold Change
Protein metabolism and transport
A0A1Z5KYM0	Xaa-pro aminopeptidase	Ornithodoros moubata	metalloaminopeptidase activity [GO:0070006]	1	−10.96
A0A293LQ15	Peptidase A1 domain-containing protein	Ornithodoros erraticus	integral component of membrane [GO:0016021]; aspartic-type endopeptidase activity [GO:0004190]	1	5.54
Carbohydrate metabolism and transport
A0A1Z5L4Q7	Alpha-mannosidase	Ornithodoros moubata	alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; mannose metabolic process [GO:0006013]	1	−3.39
A0A1Z5L0Z3	UDP-N-acetylglucosamine 4-epimerase	Ornithodoros moubata	UDP-glucose 4-epimerase activity [GO:0003978]; UDP-N-acetylglucosamine 4-epimerase activity [GO:0003974]; galactose metabolic process [GO:0006012]	2	11.10
A0A2R5LGB3	Putative chitinase	Ornithodoros turicata	chitin binding [GO:0008061]; carbohydrate metabolic process [GO:0005975]	2	9.07
Lipid metabolism and transport
A0A1Z5KX70	Lipoprotein	Ornithodoros moubata	lipid transporter activity [GO:0005319]	1	−3.28
A0A1Z5LA57	RING-type domain-containing protein	Ornithodoros moubata	metal ion binding [GO:0046872]; NAD+ binding [GO:0070403]; fatty acid metabolic process [GO:0006631]	1	4.80
L7LTX7	Transmembrane protein 188	Rhipicephalus pulchellus	cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; Nem1-Spo7 phosphatase complex [GO:0071595]; nuclear membrane [GO:0031965]; lipid metabolic process [GO:0006629]; positive regulation of protein dephosphorylation [GO:0035307]	1	9.03
Response to oxidative stress
A0A1D2AJ30	Thioredoxin peroxidase	Ornithodoros brasiliensis	peroxidase activity [GO:0004601]; peroxiredoxin activity [GO:0051920]	1	4.28
A0A1Z5LDY2	Thioredoxin-like protein 1	Ornithodoros moubata		1	3.41
A0A1Z5LEL5	Cytochrome P450	Ornithodoros moubata	heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]	1	9.74
A0A1Z5LEL5	Cytochrome P450	Ornithodoros moubata	heme binding [GO:0020037]; iron ion binding [GO:0005506]; monooxygenase activity [GO:0004497]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]	2	−10.06
A0A2R5L8R9	Putative gamma-glutamyltransferase	Ornithodoros turicata	integral component of membrane [GO:0016021]; glutathione hydrolase activity [GO:0036374]; transferase activity [GO:0016740]; glutathione catabolic process [GO:0006751]	2	−11.10
A0A1Z5L521	Uncharacterized protein	Ornithodoros moubata	acireductone dioxygenase [iron(II)-requiring] activity [GO:0010309]; methionine biosynthetic process [GO:0009086]	1	−12.99
A0A1Z5KXT5	Sulfotransferase	Ornithodoros moubata	sulfotransferase activity [GO:0008146]	1	−11.39
A0A1Z5L722	GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase	Ornithodoros moubata	GDP-L-fucose synthase activity [GO:0050577]; translation initiation factor activity [GO:0003743]; ‘de novo’ GDP-L-fucose biosynthetic process [GO:0042351]	1	2.94
A0A2R5L8F7	Gamma-glutamylcyclotransferase	Ornithodoros turicata	gamma-glutamylcyclotransferase activity [GO:0003839]; glutathione specific gamma-glutamylcyclotransferase activity [GO:0061928]; glutathione catabolic process [GO:0006751]	1	12.14
A0A1Z5L305	Sulfotransfer_1 domain-containing protein	Ornithodoros moubata	sulfotransferase activity [GO:0008146]	2	−4.36