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. 2022 Mar 16;14(3):649. doi: 10.3390/pharmaceutics14030649

Table 3.

Animal treatment plan.

Animal Group Description Treatment Route Frequency
NC Normal control
-normal pellet diet-fed
-non-diabetic rats		 PBS IV injection via tail vein Every 3 days,
total 5 times
DM Diabetic control without medication
-HFD-fed
-STZ-induced diabetes		 PBS IV injection via tail vein Every 3 days,
total 5 times
DM + GC Diabetic control with glibenclamide drug
-HFD-fed
-STZ-induced diabetes		 Glibenclamide
(10 mg/kg body weight)		 Oral gavage Every day
DM + 1MG EV Diabetic test rats
-HFD-fed
-STZ-induced diabetes		 hUC-MSC-sEVs
(1 mg/kg body weight)		 IV injection via tail vein Every 3 days,
total 5 times
DM + 0.5MG EV Diabetic test rats
-HFD-fed
-STZ-induced diabetes		 hUC-MSC-sEVs
(0.5 mg/kg body weight)		 IV injection via tail vein Every 3 days,
total 5 times
DM + 0.25MG EV Diabetic test rats
-HFD-fed
-STZ-induced diabetes		 hUC-MSC-sEVs
(0.25 mg/kg body weight)		 IV injection via tail vein Every 3 days,
total 5 times
DM + MSC Diabetic test rats
-HFD-fed
-STZ-induced diabetes		 hUC-MSCs
(2 million cells)		 IV injection via tail vein Every two weeks,
total 2 times